{"artifact_id":"L2-901","layer":"L2","parent_l1":"L1-901","title":"Partial-Reprogramming Dose–Response Twin","omega":{"dims":{"OSK_dose":[0.0,1.0],"cell_type":"fibroblast|neuron|hepatocyte","induction_days":[1,21]},"type":"range"},"epsilon":{"type":"fn","expression":"≤ 2 yr error on restored DNAm age, identity markers preserved (no dedifferentiation)"},"difficulty_score":0.9,"delta_tier":50,"fingerprint":"2147aa6e88664f7faabd8686c86d2e87501f13d47367c471208441416e96ad17","status":"testnet","submitted_by":"grand_challenge_genesis","chain_hash":null,"chain_tx_hash":null,"chain_block":null,"plain_intro":"Partial-Reprogramming Dose–Response Twin is a digital twin specification derived from principle L1-901. It defines the forward operator and a 3-dimensional parameter space Ω over which benchmarks are seeded. Each benchmark drawn from this twin is a concrete measurement instance with fixed Ω values; solvers must invert that specific measurement."}